Drug Details

General Information of the Drug (ID: DR7446)
Name
Hydroquinone
Synonyms
hydroquinone; 1,4-benzenediol; Benzene-1,4-diol; 123-31-9; Quinol; 1,4-Dihydroxybenzene; p-Benzenediol; p-Hydroquinone; p-Hydroxyphenol; p-Dihydroxybenzene; 4-Hydroxyphenol; Benzoquinol; Eldoquin; hydroquinol; Eldopaque; Phiaquin; p-Dioxybenzene; Benzohydroquinone; Dihydroquinone; Hydroquinole; Idrochinone; Tecquinol; Dihydroxybenzene; Solaquin forte; Arctuvin; Hidroquinone; Tequinol; Derma-Blanch; Tenox HQ; Hydrochinon; Hydrochinone; Artra; Eldopaque Forte; Eldoquin Forte; Diak 5; Benzene, p-dihydroxy-; 1,4-Dihydroxy-benzol; Usaf ek-356; 1,4-Diidrobenzene; p-Dioxobenzene; 1,4-Dihydroxybenzen; para-Dioxybenzene; para-Hydroquinone; Pyrogentistic acid; 1,4-Dihydroxy-benzeen; NCI-C55834; HE 5; para-Dihydroxybenzene; Black and White Bleaching Cream; Melanex; Idrochinone [Italian]; Hydrochinon [Czech, Polish]; 1,4-Dihydroxybenzen [Czech]; 1,4-Diidrobenzene [Italian]; Benzosemiquinone; 1,4-Dihydroxy-benzeen [Dutch]; 1,4-Dihydroxy-benzol [German]; UNII-XV74C1N1AE; NSC 9247; MFCD00002339; UN2662; Hydroquinone [USP]; CHEBI:17594; AI3-00072; 4-DIHYDROXYBENZENE; HQ; CHEMBL537; XV74C1N1AE; DTXSID7020716; NSC-9247; Hydroquinone [UN2662] [Poison]; Hydroquinone (USP); Hydroquinone, 99%; NCGC00015523-02; beta-quinol; Hydroquinone, 99.5%; DSSTox_CID_716; DSSTox_RID_75754; DSSTox_GSID_20716; Eldopacque; Hydroquinone (Benzene-1,4-diol); Epiquin; Sunvanish; p Benzendiol; p-Dihydroquinone; alpha-hydroquinone; para-Hydroxyphenol; CAS-123-31-9; SMR000059154; CCRIS 714; 1,4-Hydroxybenzene; HSDB 577; SR-01000075920; EINECS 204-617-8; hydroquinon; Hydroquinoue; hydroq uinone; hydroquinone gr; a-Hydroquinone; Black & White Bleaching Cream; p-Hydroxybenzene; b-Quinol; 4-Benzenediol; Hydroquinone, HQ; .beta.-Quinol; 1,4 benzenediol; Hydroquinone,(S); p-dihydroxy benzene; HQE; Hydroquinone polymer; PLQ; Artra (Salt/Mix); 1, 4-Benzenediol; HYDROP; .alpha.-Hydroquinone; phenol derivative, 4; PubChem9139; 4-hydroxyphenyl alcohol; Spectrum_001757; 4e3h; ACMC-209aok; SpecPlus_000769; 1,4-Dihydrobenzoquinone; ELDOQUIN (TN); hydroquinone for synthesis; Spectrum2_001672; Spectrum3_000656; Spectrum4_000633; Spectrum5_001430; Lopac-H-9003; 1,2 BENZOLDIOL; WLN: QR DQ; bmse000293; Epitope ID:116206; EC 204-617-8; Lopac0_000577; SCHEMBL15516; BSPBio_002291; KBioGR_001246; KBioSS_002237; 1,4-Dihydroxybenzene, XIII; Hydroquinone-1,4-Benzenediol; MLS000069815; MLS001074911; BIDD:ER0340; DivK1c_006865; Hydroquinone, LR, >=99%; SPECTRUM1504237; Hydrochinon(CZECH, POLISH); SPBio_001883; BDBM26190; Hydroquinone, puriss., 99.0%; KBio1_001809; KBio2_002237; KBio2_004805; KBio2_007373; KBio3_001511; NSC9247; Benzene-1,4-diol (Hydroquinone); HMS1922H15; HMS2093E08; HMS3261D16; LABOTEST-BB LTBB001931; Pharmakon1600-01504237; HY-B0951; ZINC5133378; Tox21_110169; Tox21_202345; Tox21_300015; Tox21_500577; ANW-18114; BBL011606; CCG-39082; NSC758707; s4580; SBB060421; STK397446; AKOS000119003; Tox21_110169_1; AM10548; AS00174; DB09526; LP00577; MCULE-3953269041; NE10177; NSC-758707; SDCCGSBI-0050559.P003; UN 2662; Hydroquinone, ReagentPlus(R), >=99%; Hydroquinone, USP, 99.0-100.5%; NCGC00015523-01; NCGC00015523-03; NCGC00015523-04; NCGC00015523-05; NCGC00015523-06; NCGC00015523-07; NCGC00015523-08; NCGC00015523-09; NCGC00015523-10; NCGC00015523-11; NCGC00015523-12; NCGC00015523-13; NCGC00015523-19; NCGC00090880-01; NCGC00090880-02; NCGC00090880-03; NCGC00090880-04; NCGC00090880-05; NCGC00254037-01; NCGC00259894-01; NCGC00261262-01; BP-21160; DA-33570; Hydroquinone, ReagentPlus(R), >=99.5%; SBI-0050559.P002; Hydroquinone, SAJ first grade, >=99.0%; EU-0100577; FT-0606877; Hydroquinone, SAJ special grade, >=99.0%; ST50214344; Hydroquinone, meets USP testing specifications; C00530; D00073; H 9003; 19538-EP2272837A1; 19538-EP2284165A1; 19538-EP2302015A1; 19538-EP2305825A1; 19538-EP2309584A1; 19538-EP2311804A2; 19538-EP2314576A1; 19538-EP2314579A1; 19538-EP2314584A1; 19538-EP2315303A1; 19538-EP2371803A1; 19538-EP2377843A1; 97871-EP2305685A1; AB00053361_08; 122680-EP2295053A1; Q419164; J-004910; J-521469; SR-01000075920-1; SR-01000075920-4; Q27102742; Z57127551; 094CADDB-59BF-4EDF-B278-59791B203EA2; F1908-0167; Hydroquinone, certified reference material, TraceCERT(R); Hydroquinone, United States Pharmacopeia (USP) Reference Standard; Hydroquinone, Pharmaceutical Secondary Standard; Certified Reference Material
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Molecular Type
Small molecule
Disease Acquired hypermelanosis [ICD-11: ED60] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C6H6O2
PubChem CID
785
Canonical SMILES
C1=CC(=CC=C1O)O
InChI
1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
InChIKey
QIGBRXMKCJKVMJ-UHFFFAOYSA-N
CAS Number
CAS 123-31-9
ChEBI ID
CHEBI:17594
TTD Drug ID
D03UOT
DrugBank ID
DB09526
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Tretinoin      Homo sapiens     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Clinical trial
                    Experimental
                    Result(s)		 Combination therapy with hydroquinone, tretinoin, and fluocinolone is the most cost-effective treatment when compared with any of its dyads or with hydroquinone alone.
Target and Pathway
Target(s) Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)  Molecule Info  [3]
Tyrosinase (TYR)  Molecule Info  [4]
BioCyc (S)-reticuline biosynthesis Click to Show/Hide
2 Eumelanin biosynthesis
3 L-dopachrome biosynthesis
KEGG Pathway Tyrosine metabolism Click to Show/Hide
2 Riboflavin metabolism
3 Metabolic pathways
4 Melanogenesis
Pathwhiz Pathway Riboflavin Metabolism Click to Show/Hide
2 Tyrosine Metabolism
Reactome Platelet degranulation Click to Show/Hide
2 Elastic fibre formation
3 PECAM1 interactions
4 Molecules associated with elastic fibres
5 Integrin cell surface interactions
6 Syndecan interactions
7 ECM proteoglycans
8 Integrin alphaIIb beta3 signaling
9 GRB2:SOS provides linkage to MAPK signaling for Integrins
10 p130Cas linkage to MAPK signaling for integrins
11 VEGFA-VEGFR2 Pathway
12 MAP2K and MAPK activation
WikiPathways Focal Adhesion Click to Show/Hide
2 Hematopoietic Stem Cell Differentiation
3 Human Complement System
4 Extracellular matrix organization
5 Arrhythmogenic Right Ventricular Cardiomyopathy
6 Integrin-mediated Cell Adhesion
7 L1CAM interactions
8 Integrin cell surface interactions
9 Integrin alphaIIb beta3 signaling
10 Dopamine metabolism
References
Reference 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Reference 2 Cost-effectiveness of a hydroquinone/tretinoin/fluocinolone acetonide cream combination in treating melasma in the United States. J Dermatolog Treat. 2010 Sep;21(5):276-81.
Reference 3 Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis. Blood. 1998 Nov 1;92(9):3268-76.
Reference 4 Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis. J Agric Food Chem. 2009 Mar 25;57(6):2200-5.
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