Molecule Details
| General Information of the Molecule | ||||
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| Name |
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)
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| Synonyms |
Platelet membrane glycoprotein IIb; Platelet membrane glycoprotein IIIa; GP
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| Gene Name |
ITGA2B; ITGB3
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| Function |
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
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| Uniprot ID | ||||
| TTD ID | ||||
| Drug(s) of This Target | ||||
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| 1 | Hydroquinone | Drug Info | Approved | Acquired hypermelanosis |
| References | ||||
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| Reference 1 | Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis. Blood. 1998 Nov 1;92(9):3268-76. | |||