Drug Combination Details
| General Information of the Combination (ID: C30192) | |||||
|---|---|---|---|---|---|
| Name | Genistein NP Info | + | Dexamethasone Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
|
Colon cancer
[ICD-11: 2B90]
|
Investigative | [1] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
|
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| In-vitro Model | COLO 320 | CVCL_1989 | Colon adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
The combined effects of dexamethasone and genistein on the induction of p21 protein and activation of p21 promoter were synergistic. | |||||
