Drug Combination Details
| General Information of the Combination (ID: C30671) | |||||
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| Name | Vincamine | + | Tamoxifen + Zafirlukast | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Vincamine NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
| Structure |
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| Disease |
Liver injury
[ICD-11: NB91]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | JNK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vivo Model | Adult female Wistar albino rats were used in this study. | |||||
| Experimental
Result(s) |
Zafirlukast and vincamine may be regarded as potential therapeutic strategies with antioxidant and anti-inflammatory activities against tamoxifen-induced oxidative damage in rat liver. | |||||
| References | ||||
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| Reference 1 | Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: Role of the JNK/ERK pathway. Life Sci. 2018 Jun 1;202:78-88. | |||
