Drug Combination Details

General Information of the Combination (ID: C31120)
Name Paclitaxel   NP Info  + Trastuzumab   Drug Info 
Structure +
Disease
Breast cancer [ICD-11: 2C60]
Phase 3 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vitro Model BT-474 CVCL_0179 Invasive breast carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Trastuzumab and paclitaxel combination showed synergistic therapy for HER2+ breast cancer.
References
Reference 1 ClinicalTrials.gov (NCT01764022) A Safety and Efficacy Study of BCD-022 With Paclitaxel Compared to Herceptin With Paclitaxel in HER2+ Metastatic Breast Cancer Patients.
Reference 2 Experimentally-driven mathematical modeling to improve combination targeted and cytotoxic therapy for HER2+ breast cancer. Sci Rep. 2019 Sep 6;9(1):12830.
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