Drug Combination Details
| General Information of the Combination (ID: C31798) | |||||
|---|---|---|---|---|---|
| Name | Vitamin D NP Info | + | Stilbenoids Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Hepatic fibrosis/cirrhosis
[ICD-11: DB93]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CREB3L1 | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | U-937 | CVCL_0007 | Adult acute monocytic leukemia | Homo sapiens | ||
| HaCaT | CVCL_0038 | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Stilbenoid compounds may have the potential to boost the innate immune response by increasing CAMP gene expression, particularly in combination with 1Alpha,25(OH)2 D3. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation. Dig Dis Sci. 2014 Oct;59(10):2462-9. | |||
