Drug Details

General Information of the Drug (ID: DR4171)
Name
Stilbenoids
Disease Influenza [ICD-11: 1E30] Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Vitamin D      Saccharomyces cerevisiae     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression CREB3L1  Molecule Info 
Pathway MAP
                    In-vitro Model U-937 CVCL_0007 Adult acute monocytic leukemia Homo sapiens
HaCaT CVCL_0038 Healthy Homo sapiens
                    Experimental
                    Result(s)		 Stilbenoid compounds may have the potential to boost the innate immune response by increasing CAMP gene expression, particularly in combination with 1Alpha,25(OH)2 D3.
Target and Pathway
Target(s) Human Deoxyribonucleic acid (hDNA)  Molecule Info  [3]
References
Reference 1 In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum. Planta Med. 2010 Nov;76(16):1874-6.
Reference 2 Vitamin D and S-farnesylthiosalicylic acid have a synergistic effect on hepatic stellate cells proliferation. Dig Dis Sci. 2014 Oct;59(10):2462-9.
Reference 3 A structural insight into major groove directed binding of nitrosourea derivative nimustine with DNA: a spectroscopic study. PLoS One. 2014 Aug 7;9(8):e104115.
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