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Molecule Details

General Information of the Molecule
Name
Human Deoxyribonucleic acid (hDNA)
Uniprot ID
NOUNIPROTAC
TTD ID
T86836
Natural Product(s) of This Target
1 Daunorubicin  NP Info  Approved Streptomyces peucetius
2 Streptozocin  NP Info  Approved Streptomyces achromogenes
Drug(s) of This Target
1 1,3-bis(2-chloroethyl)-1-nitrosourea  Drug Info  Approved Hepatocellular carcinoma
2 Bleomycin  Drug Info  Approved Hodgkin lymphoma
3 Busulfan  Drug Info  Approved Myelofibrosis
4 Carboplatin  Drug Info  Approved Ovarian cancer
5 Cisplatin  Drug Info  Approved Bladder cancer
6 Cyclophosphamide  Drug Info  Approved Solid tumour/cancer
7 Dacarbazine  Drug Info  Approved Melanoma
8 Decitabine  Drug Info  Approved Myelodysplastic syndrome
9 Mitomycin C  Drug Info  Approved Solid tumour/cancer
10 Oxaliplatin  Drug Info  Approved Colorectal cancer
11 Pirarubicin  Drug Info  Approved Breast cancer
12 PR-104A  Drug Info  Investigative Hepatocellular carcinoma
13 Procarbazine  Drug Info  Approved Hodgkin lymphoma
14 Stilbenoids  Drug Info  Investigative Influenza
15 Temozolomide  Drug Info  Approved Brain cancer
References
Reference 1 31P NMR spectra of ethidium, quinacrine, and daunomycin complexes with poly(adenylic acid).poly(uridylic acid) RNA duplex and calf thymus DNA. Biochemistry. 1989 Apr 4;28(7):2804-12.
Reference 2 Hydrodynamics-based transfection of pancreatic duodenal homeobox 1 DNA improves hyperglycemia and is associated with limited complications in diabe... Endocr J. 2009;56(6):783-90.
Reference 3 Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. Eur J Cancer. 1991;27(12):1658-62.
Reference 4 Bleomycin and talisomycin sequence-specific strand scission of DNA: a mechanism of double-strand cleavage. Cancer Res. 1982 Jul;42(7):2779-85.
Reference 5 DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 2004 May;95(5):454-8.
Reference 6 Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.Clin Cancer Res.2010 Oct 1;16(19):4899-905.
Reference 7 Cisplatin and DNA repair in cancer chemotherapy.Trends Biochem Sci.1995 Oct;20(10):435-9.
Reference 8 O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts. Int J Cancer. 1998 Sep 11;77(6):919-22.
Reference 9 Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mono... Melanoma Res. 2011 Dec;21(6):502-8.
Reference 10 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
Reference 11 Assessment of cell viability, lipid peroxidation and quantification of DNA fragmentation after the treatment of anticancerous drug mitomycin C and ... Exp Toxicol Pathol. 2010 Sep;62(5):503-8.
Reference 12 Structures of oxaliplatin-oligonucleotide adducts from DNA.J Mass Spectrom.2012 Oct;47(10):1282-93.
Reference 13 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
Reference 14 Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A. Mol Cancer Ther. 2009 Jun;8(6):1714-23.
Reference 15 Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations... DNA Repair (Amst). 2009 Jan 1;8(1):72-86.
Reference 16 A structural insight into major groove directed binding of nitrosourea derivative nimustine with DNA: a spectroscopic study. PLoS One. 2014 Aug 7;9(8):e104115.
Reference 17 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China