Drug Combination Details
| General Information of the Combination (ID: C32613) | |||||
|---|---|---|---|---|---|
| Name | Ferulic acid NP Info | + | Atorvastatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Obesity
[ICD-11: 5B81]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | IL6 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| In-vivo Model | Male Swiss albino mice were given a diet containing high fat. | |||||
| Experimental
Result(s) |
Simultaneous treatment with AS, F and their combination protected against HFD induced weight gain and oxidative stress. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Promising role of ferulic acid, atorvastatin and their combination in ameliorating high fat diet-induced stress in mice. Life Sci. 2013 May 20;92(17-19):938-49. | |||
