Drug Combination Details

General Information of the Combination (ID: C34625)
Name Cepharanthine   NP Info  + S-1   Drug Info 
Structure +
Disease
Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Augmenting Drug Sensitivity     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression DPYD  Molecule Info 
Pathway MAP
Down-regulation Expression TYMS  Molecule Info 
Pathway MAP
                    In-vitro Model HSC-2 CVCL_1287 Oral cavity squamous cell carcinoma Homo sapiens
B88 Oral squamous cell carcinoma Homo sapiens
                    In-vivo Model B88 or HSC2 cells (1*106) were suspended in 0.1 mL of serum-free medium and injected into the subcutaneous tissue of 5-week-old nude mice.
                    Experimental
                    Result(s)		 Combined therapy of cepharanthine and S-1 exerted antitumor effects on human OSCC xenografts markedly and significantly induced apoptotic cells in tumors treated with cepharanthine plus S-1.
References
Reference 1 Effects of cepharanthine alone and in combination with fluoropyrimidine anticancer agent, S-1, on tumor growth of human oral squamous cell carcinoma xenografts in nude mice. Anticancer Res. 2009 Apr;29(4):1263-70.
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