Drug Details
| General Information of the Drug (ID: DR8070) | ||||
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| Name |
S-1
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| Synonyms |
Fluoropyrimidine anticancer agent
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| Disease | Gastrointestinal stromal tumor [ICD-11: 2B5B] | Phase 3 | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Cepharanthine | Stephania delavayi | Click to Show/Hide the Molecular Data of This NP | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Down-regulation | Expression | DPYD | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TYMS | Molecule Info |
Pathway MAP
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| In-vitro Model | HSC-2 | CVCL_1287 | Oral cavity squamous cell carcinoma | Homo sapiens | ||
| B88 | Oral squamous cell carcinoma | Homo sapiens | ||||
| In-vivo Model | B88 or HSC2 cells (1*106) were suspended in 0.1 mL of serum-free medium and injected into the subcutaneous tissue of 5-week-old nude mice. | |||||
| Experimental
Result(s) |
Combined therapy of cepharanthine and S-1 exerted antitumor effects on human OSCC xenografts markedly and significantly induced apoptotic cells in tumors treated with cepharanthine plus S-1. | |||||
| Peginterferon alpha 2b | Homo sapiens | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
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| Experimental
Result(s) |
Combination therapy with S-1 and PEG-IFN is effective and feasible, and is therefore a promising regimen for advanced HCC. | |||||
| Target and Pathway | ||||
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| Target(s) | ATP synthase F(0) complex C1 (ATP5MC1) | Molecule Info | [4] | |
| ATP synthase F(0) complex C2 (ATP5MC2) | Molecule Info | [4] | ||
| ATP synthase F(0) complex C3 (ATP5MC3) | Molecule Info | [4] | ||
