Drug Combination Details

General Information of the Combination (ID: C35498)
Name Salicylic acid   NP Info  + 5-fluorouracil   Drug Info 
Structure +
Disease
Actinic keratoses on the hands and/or forearms [ICD-11: EK90]
Phase 3 [1]
Common warts [ICD-11: 1E80]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vivo Model Medical record review
                    Experimental
                    Result(s)		 It was observed that the twice-daily application of topical fluorouracil and salicylic acid is a safe and effective treatment for verruca plantaris.
References
Reference 1 ClinicalTrials.gov (NCT02289768) Study To Evaluate The Efficacy And Safety Of Actikerall Solution In Patients With Grade I-II Actinic Keratoses.
Reference 2 Treatment of verruca plantaris with a combination of topical fluorouracil and salicylic acid. J Am Podiatr Med Assoc. Jul-Aug 2005;95(4):366-9.
Reference 3 Low-dose 5-fluorouracil in combination with salicylic acid for the treatment of actinic keratoses on the hands and/or forearms - results of a non-interventional study. J Eur Acad Dermatol Venereol. 2017 Mar;31(3):455-462.
Reference 4 Combination therapy with 5-fluorouracil and salicylic acid in a treatment-resistant case of filiform facial warts. Dermatol Ther. 2020 Mar;33(2):e13235.
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