Natural Product (NP) Details

General Information of the NP (ID: NP5868)
Name
Salicylic acid
Synonyms
salicylic acid; 2-Hydroxybenzoic acid; 69-72-7; o-hydroxybenzoic acid; 2-Carboxyphenol; o-Carboxyphenol; Rutranex; Salonil; Retarder W; Keralyt; Duoplant; Freezone; Saligel; Ionil; Psoriacid-S-stift; Benzoic acid, 2-hydroxy-; Stri-Dex; Salicylic acid soap; Salicylic acid collodion; Verrugon; Phenol-2-carboxylic acid; Acidum salicylicum; Trans-Ver-Sal; Orthohydroxybenzoic acid; 2-Hydroxybenzenecarboxylic acid; Acido salicilico; Ionil-Plus; Salicylic acid, tech.; Kyselina salicylova; Clear away wart remover; Duofil wart remover; Domerine; Sebucare; Duofilm; Sebulex; Salicyclic acid; Ionil plus; Dr. Scholl's corn removers; Kyselina salicylova [Czech]; Dr. Scholl's callus removers; Dr. Scholl's wart remover kit; Kyselina 2-hydroxybenzoova; Occlusal; Acido salicilico [Italian]; Advanced pain relief corn removers; Caswell No. 731; 2-hydroxy-benzoic acid; Kyselina 2-hydroxybenzoova [Czech]; Advanced pain relief callus removers; Acido o-idrossibenzoico [Italian]; NSC 180; Salicylic acid & Sulfur Soap; MFCD00002439; CCRIS 6714; HSDB 672; AI3-02407; UNII-O414PZ4LPZ; EPA Pesticide Chemical Code 076602; BRN 0774890; Salicylic Acid-d4; CHEBI:16914; CHEMBL424; O414PZ4LPZ; MLS000069653; NSC180; Salicylic acid inclusion complex; K 537; NSC-180; ATA fraction 10, ammonium salt; NCGC00159447-05; SMR000059163; Mediplast pads; Salicylic acid, 99+%; Akurza Lotion; Hydrisalic Gel; Akurza Cream; Salex Lotion; Salex Cream; DSSTox_CID_6368; DuoPlant Gel; DHS Sal Shampoo; DSSTox_RID_78106; P&S Shampoo; DSSTox_GSID_26368; Salicylic acid [USAN:JAN]; Acido o-idrossibenzoico; Durasal; salicylic-acid; Salicylic acid, 99+%, ACS reagent; salicylicum acidum; CAS-69-72-7; Propa pH Peel-Off Acne Mask; NSC629474; phenol derivative, 7; Salicylic acid (TN); Benzoic acid, 2-hydroxy-, ion(1-); 2,3,4,5-tetradeuterio-6-hydroxybenzoic acid; EINECS 200-712-3; Salicylic acid [USP:JAN]; Azurechelin; Salicylic acid (6CI,8CI); Anti-blemish; Salicylic acid rs; hydroxy-benzoic acid; ortho-salicylic acid; CMC_13852; Fostex (Salt/Mix); Pernox (Salt/Mix); Duofilm Wart Remover; Phenol-2-carboxylate; Duofilm (Salt/Mix); Salicylic Acid,(S); Sebulex (Salt/Mix); 2-hydroxobenzoic acid; Domerine (Salt/Mix); Sebucare (Salt/Mix); 2-Hydroxybenzoate, I; Natural Salicylic Acid; o-hydroxy benzoic acid; 2-hydroxy benzoic acid; Spectrum_000948; ACMC-1AZIK; Opera_ID_582; Salicylic acid ACS grade; [O]C(=O)c1ccccc1O; WLN: QVR BQ; Benzoic acid, o-hydroxy-; Bazuka Extra Strength Gel; 2-Hydroxybenzenecarboxylate; bmse000252; Epitope ID:124929; Retarder SAX (Salt/Mix); UPCMLD-DP126; EC 200-712-3; SCHEMBL1967; Oprea1_040343; KBioSS_001428; ARONIS27188; BIDD:ER0602; DivK1c_000301; Salicylic acid (JP17/USP); 2-Hydroxybenzoic Acid, Natural; FEMA3985; GTPL4306; SGCUT00012; ZINC1554; Salicylic acid, >=99%, FG; Salicylic acid, LR, >=99%; component of Tinver (Salt/Mix); DTXSID7026368; FEMA NO. 3985; UPCMLD-DP126:001; BDBM26193; component of Keralyt (Salt/Mix); KBio1_000301; KBio2_001428; KBio2_003996; KBio2_006564; Alpha/Beta Hydroxy Acids (Glycolic Acid, Salicylic Acid); E9A559BE-383B-4F83-BC02-3031D03D558A; NINDS_000301; HMS2233A10; HMS3373M19; HMS3885B08; KUC106694N; Salicylic acid, p.a., 99.0%; Benzoic acid, 2-hydroxy- (9CI); BCP09067; HY-B0167; to_000004; Lamivudine impurity, salicylic acid-; Tox21_113453; Tox21_201471; Tox21_303109; ANW-43703; s4539; SBB052826; STK258681; AKOS000118979; Salicylic acid, BioXtra, >=99.0%; CCG-212792; DB00936; MCULE-8407868694; NE10196; IDI1_000301; SMP2_000145; NCGC00159447-02; NCGC00159447-04; NCGC00159447-06; NCGC00257065-01; NCGC00259022-01; AK112186; BP-12826; KSC-11-207-4; Lamivudine related compound salicylic acid; Salicylic acid & Sulfur Soap (Salt/Mix); Salicylic acid, ACS reagent, >=99.0%; Salicylic acid, plant cell culture tested; Salicylic acid, ReagentPlus(R), >=99%; TS-03583; Salicylic Acid 1.0 mg/ml in Acetonitrile; SBI-0051510.P003; FT-0645123; FT-0674502; FT-0674503; Salicylic acid, tested according to Ph.Eur.; ST51046715; Salicylic acid, SAJ first grade, >=99.0%; 3253-EP2269610A2; 3253-EP2269988A2; 3253-EP2270002A1; 3253-EP2270006A1; 3253-EP2270008A1; 3253-EP2270011A1; 3253-EP2270113A1; 3253-EP2272935A1; 3253-EP2275401A1; 3253-EP2275413A1; 3253-EP2275420A1; 3253-EP2277867A2; 3253-EP2280003A2; 3253-EP2280008A2; 3253-EP2280010A2; 3253-EP2281563A1; 3253-EP2281816A1; 3253-EP2284146A2; 3253-EP2284147A2; 3253-EP2284160A1; 3253-EP2284178A2; 3253-EP2284179A2; 3253-EP2287156A1; 3253-EP2289510A1; 3253-EP2289883A1; 3253-EP2289890A1; 3253-EP2292592A1; 3253-EP2292597A1; 3253-EP2292617A1; 3253-EP2295053A1; 3253-EP2295401A2; 3253-EP2295416A2; 3253-EP2295424A1; 3253-EP2295433A2; 3253-EP2298734A2; 3253-EP2298735A1; 3253-EP2298748A2; 3253-EP2298757A2; 3253-EP2298758A1; 3253-EP2298759A1; 3253-EP2298764A1; 3253-EP2298765A1; 3253-EP2301931A1; 3253-EP2301937A1; 3253-EP2301940A1; 3253-EP2305243A1; 3253-EP2305248A1; 3253-EP2305257A1; 3253-EP2305646A1; 3253-EP2305651A1; 3253-EP2305655A2; 3253-EP2305662A1; 3253-EP2305663A1; 3253-EP2305664A1; 3253-EP2305675A1; 3253-EP2308851A1; 3253-EP2308854A1; 3253-EP2308873A1; 3253-EP2308875A1; 3253-EP2311807A1; 3253-EP2311809A1; 3253-EP2311810A1; 3253-EP2311814A1; 3253-EP2311831A1; 3253-EP2311842A2; 3253-EP2314574A1; 3253-EP2314588A1; 3253-EP2316457A1; 3253-EP2316458A1; 3253-EP2316459A1; 3253-EP2316825A1; 3253-EP2316826A1; 3253-EP2316827A1; 3253-EP2316828A1; 3253-EP2316836A1; 3253-EP2372017A1; 3253-EP2380874A2; C00805; D00097; Salicylic acid, Vetec(TM) reagent grade, 98%; 44642-EP2281819A1; 44642-EP2292619A1; 44642-EP2305659A1; 44642-EP2311818A1; AB00489876_15; BENZOIC ACID,2-HYDROXY SALICYLIC ACID; Salicylic acid, puriss. p.a., >=99.0% (T); 197900-EP2269975A2; 197900-EP2269997A2; 197900-EP2275415A2; Q193572; component of Solarcaine first aid spray (Salt/Mix); J-509667; component of Fostex medicated bar and cream (Salt/Mix); F2191-0216; Salicylic acid, certified reference material, TraceCERT(R); UNII-I3P9R8317T component YGSDEFSMJLZEOE-UHFFFAOYSA-N; Salicylic acid, British Pharmacopoeia (BP) Reference Standard; Salicylic acid, European Pharmacopoeia (EP) Reference Standard; Salicylic acid, United States Pharmacopeia (USP) Reference Standard; Salicylic acid, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material; Salicylic acid, Pharmaceutical Secondary Standard; Certified Reference Material; 8052-31-1; Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance)
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Species Origin Salix abscondita ...     Click to Show/Hide
Salix abscondita
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Malpighiales
Family: Salicaceae
Genus: Salix
Species: Salix abscondita
Disease Seborrhoeic dermatitis [ICD-11: EA81] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C7H6O3
PubChem CID
338
Canonical SMILES
C1=CC=C(C(=C1)C(=O)O)O
InChI
1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
InChIKey
YGSDEFSMJLZEOE-UHFFFAOYSA-N
CAS Number
CAS 69-72-7
ChEBI ID
CHEBI:16914
Herb ID
HBIN042852
SymMap ID
SMIT00123
TCMSP ID
MOL001801
TTD Drug ID
D07HBX
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Cisplatin      Bladder cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression AKT1  Molecule Info 
Pathway MAP
Up-regulation Expression CASP3  Molecule Info 
Pathway MAP
Up-regulation Expression PARP1  Molecule Info 
Pathway MAP
                    In-vitro Model HeLa CVCL_0030 Endocervical adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 Reduction in cisplatin concentration, enhanced anti-cancer effects and UHRF1 downregulation due to synergistic interaction between salicylic acid and cisplatin underscores the therapeutic importance of the combination to overcome chemo-resistance and side effects of cisplatin.
          Methylene blue      Acquired methaemoglobinaemia     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model MDA-MB-231 CVCL_0062 Breast adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 Cancer cell killing efficiency of MB increases in the combination with SA due to reduction prevention and stabilization of monomeric form of MB.
          5-fluorouracil      Solid tumour/cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [4]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Medical record review
                    Experimental
                    Result(s)		 It was observed that the twice-daily application of topical fluorouracil and salicylic acid is a safe and effective treatment for verruca plantaris.
Target and Pathway
Target(s) Carbonic anhydrase (CA)  Molecule Info  [5]
Prostaglandin G/H synthase 1 (COX-1)  Molecule Info  [6]
BioCyc C20 prostanoid biosynthesis Click to Show/Hide
KEGG Pathway Arachidonic acid metabolism Click to Show/Hide
2 Metabolic pathways
3 Platelet activation
4 Serotonergic synapse
NetPath Pathway TGF_beta_Receptor Signaling Pathway Click to Show/Hide
Panther Pathway Inflammation mediated by chemokine and cytokine signaling pathway Click to Show/Hide
Pathwhiz Pathway Arachidonic Acid Metabolism Click to Show/Hide
WikiPathways Prostaglandin Synthesis and Regulation Click to Show/Hide
2 Arachidonic acid metabolism
3 Phase 1 - Functionalization of compounds
4 Eicosanoid Synthesis
5 Selenium Micronutrient Network
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4306).
Reference 2 Synergistic anti-cancer action of salicylic acid and cisplatin on HeLa cells elucidated by network pharmacology and in vitro analysis. Life Sci. 2021 Oct 1;282:119802.
Reference 3 Combination photodynamic therapy of human breast cancer using salicylic acid and methylene blue. Spectrochim Acta A Mol Biomol Spectrosc. 2017 Sep 5;184:198-203.
Reference 4 Treatment of verruca plantaris with a combination of topical fluorouracil and salicylic acid. J Am Podiatr Med Assoc. Jul-Aug 2005;95(4):366-9.
Reference 5 Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6.
Reference 6 The C50T polymorphism of the cyclooxygenase-1 gene and the risk of thrombotic events during low-dose therapy with acetyl salicylic acid. Thromb Haemost. 2008 Jul;100(1):70-5.
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