Molecule Details

Natural Product(s) of This Target
1 Curcumin  NP Info  Phase 3 Hellenia speciosa
2 Ellagic acid  NP Info  Investigative Lagerstroemia speciosa
3 Ferulic acid  NP Info  Investigative Ferula sinkiangensisK
4 Gallic acid  NP Info  Investigative Equisetum arvense
5 Salicylic acid  NP Info  Approved Salix abscondita
Drug(s) of This Target
1 Folfox  Drug Info  Approved Colorectal cancer
References
Reference 1 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
Reference 2 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
Reference 3 Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6.
Reference 4 Combined 3-O-acetylbetulin treatment and carbonic anhydrase IX inhibition results in additive effects on human breast cancer cells. Chem Biol Interact. 2021 Jan 5;333:109326.