Drug Details

General Information of the Drug (ID: DR9368)
Name
Folfox
Synonyms
Folfox protocol; Folfox regimen; FOLFOX-4 protocol; FOLFOX-6 protocol; FOLFOX-7 protocol; Folfox; FOLFOX-4; FOLFOX-6; FOLFOX-7; C410216000; Fluorouracil regimen with leucovorin calcium and oxaliplatin
    Click to Show/Hide
Molecular Type
Small molecule
Disease Colorectal cancer [ICD-11: 2B91] Approved [1]
Structure
Click to Download Mol
2D MOL

3D MOL

    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
C34H42FN9O13Pt
PubChem CID
135659064
Canonical SMILES
[CH2-]C1CCCCC1[CH2-].C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.C1=C(C(=O)NC(=O)N1)F.C(=O)(C(=O)O)O.[Pt+2]
InChI
1S/C20H23N7O7.C8H14.C4H3FN2O2.C2H2O4.Pt/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;1-7-5-3-4-6-8(7)2;5-2-1-6-4(9)7-3(2)8;3-1(4)2(5)6;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);7-8H,1-6H2;1H,(H2,6,7,8,9);(H,3,4)(H,5,6);/q;-2;;;+2/t12?,13-;7-,8-;;;/m01.../s1
InChIKey
YXTKHLHCVFUPPT-YYFJYKOTSA-N
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug
          Glycine      Musa x paradisiaca     Click to Show/Hide the Molecular Data of This NP
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression FABP3  Molecule Info 
Pathway MAP
                    In-vitro Model Human cardiac myocytes Healthy Homo sapiens
                    In-vivo Model For a xenograft model, CC531 cells were injected into the right liver lobe of seven-week-old male Wag/Rij rats.
                    Experimental
                    Result(s)		 Dietary glycine protects the heart against FOLFOX-induced injury during treatment for CRLM.
Target and Pathway
Target(s) Carbonic anhydrase (CA)  Molecule Info  [3]
References
Reference 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2009
Reference 2 Dietary Glycine Prevents FOLFOX Chemotherapy-Induced Heart Injury: A Colorectal Cancer Liver Metastasis Treatment Model in Rats. Nutrients. 2020 Aug 28;12(9):2634.
Reference 3 Combined 3-O-acetylbetulin treatment and carbonic anhydrase IX inhibition results in additive effects on human breast cancer cells. Chem Biol Interact. 2021 Jan 5;333:109326.
 Download Picture         KEGG Link