Drug Combination Details
| General Information of the Combination (ID: C37324) | |||||
|---|---|---|---|---|---|
| Name | Ferulic acid NP Info | + | Insulin Drug Info | ||
| Structure |
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+ |
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| Disease |
Diabetic neuropathy
[ICD-11: 8C03]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Activity | COX-2 | Molecule Info |
Pathway MAP
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| In-vivo Model | Overnight fasted rats (Adult male Sprague-Dawley rats) were injected intra-peritoneally with strepto zotocin (55 mg/kg) dissolved in citrate buffer (pH 4.5, 0.1 M) to induce diabetes. | |||||
| Experimental
Result(s) |
Diabetic rats treated with insulin-FA combination demonstrated more pronounced beneficial effects as compared to either agent alone. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Beneficial effects of ferulic acid alone and in combination with insulin in streptozotocin induced diabetic neuropathy in Sprague Dawley rats. Life Sci. 2020 Aug 15;255:117856. | |||
