Drug Combination Details

General Information of the Combination (ID: C40727)
Name Paclitaxel   NP Info  + Cisplatin   Drug Info 
Structure +
Disease
Ovarian cancer [ICD-11: 2C73]
Phase 3 [1]
Colorectal cancer [ICD-11: 2B91]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vitro Model LoVo CVCL_0399 Colon adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 Paclitaxel in combination with cisplatin showed the most cytotoxic effect in colorectal cancer cells.
References
Reference 1 ClinicalTrials.gov (NCT00002717) Paclitaxel and Cisplatin in Treating Patients With Stage III or Stage IV Ovarian Cancer or Primary Peritoneal Cancer.
Reference 2 Cytotoxicity of paclitaxel in combination with cisplatin and a new Pt-mercaptopyridine complex. Anticancer Res. Sep-Oct 2002;22(5):2783-8.
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