Drug Combination Details

General Information of the Combination (ID: C41250)
Name Farnesol   NP Info  + Fluconazole   Drug Info 
Structure +
Disease
Candidosis [ICD-11: 1F23]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Up-regulation Expression FDFT1  Molecule Info 
Pathway MAP
                    In-vitro Model Candida albicans SC5314 Microorganism model Candida albicans
                    Experimental
                    Result(s)		 FAR and FAR/FLC affected fitness of C. albicans biofilm and the ERG gene regulation.
                    Experiment 2 Reporting the Effect of This Combination [2]
                    In-vitro Model Candida albicans fluconazole-sensitive 1216 Microorganism model Candida albicans
Candida albicans fluconazole-resistant 21616 Microorganism model Candida albicans
Candida albicans fluconazole-sensitive 10431 Microorganism model Candida albicans
Candida albicans fluconazole-resistant 27700 Microorganism model Candida albicans
                    Experimental
                    Result(s)		 Farnesol was not beneficial in combination with fluconazole for fluconazole-susceptible isolates, but partially increased fluconazole activity against one fluconazole-resistant isolate, but not the other one.
References
Reference 1 The impact of farnesol in combination with fluconazole on Candida albicans biofilm: regulation of ERG20, ERG9, and ERG11 genes. Folia Microbiol (Praha). 2018 May;63(3):363-371.
Reference 2 The in vitro and in vivo efficacy of fluconazole in combination with farnesol against Candida albicans isolates using a murine vulvovaginitis model. J Microbiol. 2016 Nov;54(11):753-760.
 Download Picture         KEGG Link      
 Download Picture         KEGG Link