Drug Combination Details
| General Information of the Combination (ID: C41705) | |||||
|---|---|---|---|---|---|
| Name | Liquiritin NP Info | + | TNF-related apoptosis inducing ligand Drug Info | ||
| Structure |
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+ |
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| Disease |
Stomach cancer
[ICD-11: 2B72]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Induction | Apoptosis | ||||
| Induction | ROS generation | |||||
| In-vitro Model | AGS | CVCL_0139 | Gastric adenocarcinoma | Homo sapiens | ||
| SNU-216 | CVCL_3946 | Gastric tubular adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
In combination, the two drugs functioned synergistically to impede the progression and growth of human gastric cancer cells in vitro and gastric cancer cell xenograft nude mice in vivo. | |||||
