Natural Product (NP) Details
| General Information of the NP (ID: NP9253) | |||||
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| Name |
Liquiritin
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| Synonyms |
Liquiritin; Liquiritoside; 551-15-5; 7-Hydroxyflavanone 4'-O-glucoside; Likviritin; UNII-T0O79T74CD; CHEBI:80845; T0O79T74CD; 4',7-Dihydroxyflavanone 4'-(beta-D-glucopyranoside); (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyphenyl]chroman-4-one; 4'-O-beta-D-glucopyranosyl-7-hydroxyflavan-4-one; Likviriton; 4H-1-Benzopyran-4-one,2-[4-(b-D-glucopyranosyloxy)phenyl]-2,3-dihydro-7-hydroxy-, (2S)-; (S)-7-hydroxy-2-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)chroman-4-one; 4',7-Dihydroxyflavanone 4'-(beta-D-glucoside); Liquiritigenin-4'-O-glucoside; MLS000575018; CHEMBL511995; Liquiritigenin-4'-beta-glucoside; DTXSID40203619; HMS2214B11; liquiritigenin-4'-beta-D-glucoside; HY-N0376; ZINC8829785; BDBM50479044; MFCD00210526; s3930; AKOS015897117; CCG-268869; (S)-2-(4-(beta-D-Glucopyranosyloxy)phenyl)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one; AS-74201; AT-22713; SMR000232362; 7-hydroxyflavanone 4'-O-beta-D-glucoside; liquiritigenin 4'-O-beta-D-glucopyranoside; CS-0008920; X1173; A12084; C16989; Q-100625; Q3242316; Liquiritin, from Glycyrrhizae root (licorice root), >=98% (HPLC); 4-[(2S)-7-hydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl]phenyl beta-D-glucopyranoside; (2S)-7-hydroxy-2-(4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3,4-dihydro-2H-1-benzopyran-4-one; (S)-7-hydroxy-2-(4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)phenyl)chroman-4-one; (S)-7-Hydroxy-2-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chroman-4-one; 4H-1-Benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)phenyl)-2,3-dihydro-7-hydroxy-, (S)-
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| Species Origin | Glycyrrhiza uralensis ... | Click to Show/Hide | |||
| Glycyrrhiza uralensis | |||||
| Disease | Rheumatoid arthritis [ICD-11: FA20] | Investigative | [1] | ||
| Structure |
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| Formula |
C21H22O9
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| PubChem CID | |||||
| Canonical SMILES |
C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O
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| InChI |
1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1
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| InChIKey |
DEMKZLAVQYISIA-ZRWXNEIDSA-N
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| CAS Number |
CAS 551-15-5
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| TNF-related apoptosis inducing ligand | Lung cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Biological
Regulation |
Induction | Apoptosis | ||||
| Induction | ROS generation | |||||
| In-vitro Model | AGS | CVCL_0139 | Gastric adenocarcinoma | Homo sapiens | ||
| SNU-216 | CVCL_3946 | Gastric tubular adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
In combination, the two drugs functioned synergistically to impede the progression and growth of human gastric cancer cells in vitro and gastric cancer cell xenograft nude mice in vivo. | |||||
