Drug Combination Details
| General Information of the Combination (ID: C41820) | |||||
|---|---|---|---|---|---|
| Name | Honokiol NP Info | + | Cisplatin Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Ovarian cancer
[ICD-11: 2C73]
|
Investigative | [1] | ||
|
Lung cancer
[ICD-11: 2C25]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | PECAM1 | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
The combination of honokiol with DDP can enhance the antitumor activity. | |||||
| Experiment 2 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | SK-OV-3 | CVCL_0532 | Ovarian serous cystadenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Combining liposomal honokiol with cisplatin enhances therapeutic effectiveness in ovarian carcinoma. | |||||
