Drug Combination Details
| General Information of the Combination (ID: C42261) | |||||
|---|---|---|---|---|---|
| Name | Cantharidin NP Info | + | Gamma-ray irradiation Drug Info | ||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Reduction | Number of Treg cells and myeloid suppressor cells | ||||
| In-vivo Model | Lewis lung cancer cells (1 * 106) was inoculated into the right hind leg of C57BL/6 mice. | |||||
| Experimental
Result(s) |
Combining radiotherapy and cantharidin may have synergistic effects in driving tumor rejection by increasing T-cell infiltration, proliferation and cytokine production. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination radiotherapy and cantharidin inhibits lung cancer growth through altering tumor infiltrating lymphocytes. Future Oncol. 2017 Jun;13(13):1173-1180. | |||
