Drug Details
| General Information of the Drug (ID: DR5586) | ||||
|---|---|---|---|---|
| Name |
Gamma-ray irradiation
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| Molecular Type |
Radiotherapy
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| Disease | Brain metastases [ICD-11: 2D50] | Phase 3 | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Cantharidin | Lytta vesicatoria | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Biological
Regulation |
Reduction | Number of Treg cells and myeloid suppressor cells | ||||
| In-vivo Model | Lewis lung cancer cells (1 * 106) was inoculated into the right hind leg of C57BL/6 mice. | |||||
| Experimental
Result(s) |
Combining radiotherapy and cantharidin may have synergistic effects in driving tumor rejection by increasing T-cell infiltration, proliferation and cytokine production. | |||||
| Cucurbitacin B | Cucurbitaceae | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| In-vitro Model | SK-BR-3 | CVCL_0033 | Breast adenocarcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Cucurbitacin B causes increased radiation sensitivity of human breast cancer cells via G2/M cell cycle arrest. | |||||
| Phytosphingosine | Patiria pectinifera | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [4] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
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| Molecule(s)
Regulation |
Up-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | AIF nuclear translocation | ||||
| Induction | Bax mitochondrial relocalization | |||||
| Induction | ROS accumulation | |||||
| In-vitro Model | Jurkat | CVCL_0065 | T acute lymphoblastic leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Enhancement of cell death of radiation-resistant cancer cells by phytosphingosine treatment in combination with gamma-radiation is mediated by nuclear translocation of AIF, which is in turn mediated both by ROS-dependent Bax relocalization and ROS-independent PARP-1 activation. | |||||
| β. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug | ||||||
| Amentoflavone | Gingko biloba | Click to Show/Hide the Molecular Data of This NP | ||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [5] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
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| Molecule(s)
Regulation |
Up-regulation | Expression | TNFAIP2 | Molecule Info | ||
| In-vivo Model | Male C57BL/6 mice(18-22g) were exposed to 60Co Gamma-irradiation at a dose of 7.5 Gy or 3 Gy and the dose rate was 1.58 Gy/min | |||||
| Experimental
Result(s) |
AMF is a potential protective agent against radiation injury. | |||||
