Drug Combination Details
| General Information of the Combination (ID: C42640) | |||||
|---|---|---|---|---|---|
| Name | Genistein NP Info | + | Trichostatin A Drug Info | ||
| Structure |
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+ |
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| Disease |
Lung cancer
[ICD-11: 2C25]
|
Investigative | [1] | ||
|
Laryngeal cancer
[ICD-11: 2C23]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| In-vitro Model | HEp-2 | CVCL_1906 | Laryngeal carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. | |||||
| Experiment 2 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP10 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1. | |||||
