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Drug Combination Details

General Information of the Combination (ID: C43100)
Name Xylitol   NP Info  + Chlorhexidine   Drug Info 
Structure +
Disease
Dental disease [ICD-11: DA08]
Phase 3 [1]
Staphylococcus infection [ICD-11: 1C41]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    Experimental
                    Result(s)
The XYL + CHX combination was efficient and superior to single treatments in controlling biofilm and suppressing S. mutans.
References
Reference 1 ClinicalTrials.gov (NCT00067340) Caries Transmission Prevention in Alaska Native Infants.
Reference 2 Antimicrobial effects of the combination of chlorhexidine and xylitol. Br Dent J. 2010 Dec 18;209(12):E19.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China