Natural Product (NP) Details

General Information of the NP (ID: NP0075)
Name
Xylitol
Synonyms
xylitol; ribitol; adonitol; 87-99-0; Xylite; 488-81-3; D-Xylitol; Adonite; Adonit; D-ribitol; Eutrit; Klinit; Xyliton; Xylit; Xylite (sugar); Kannit; Newtol; 1,2,3,4,5-pentanepentol; Xylisorb; L-ribitol; (2R,3R,4S)-Pentane-1,2,3,4,5-pentaol; (2R,3S,4S)-Pentane-1,2,3,4,5-pentaol; meso-ribitol; meso-xylitol; L-xylitol; D-Adonitol; UNII-353ZQ9TVDA; UNII-VCQ006KQ1E; NSC 25283; BRN 1720523; CHEBI:15963; CHEBI:17151; (2S,4R)-pentane-1,2,3,4,5-pentol; 1,2,3,4,5-Pentahydroxypentane; (2R,3s,4S)-pentane-1,2,3,4,5-pentol; MFCD00064291; MFCD00064292; 353ZQ9TVDA; VCQ006KQ1E; Xylooligosaccharide; Adonitol, 99+%; Xylitol, 99+%; (2R,3r,4S)-pentane-1,2,3,4,5-pentol; 4-01-00-02832 (Beilstein Handbook Reference); C5H12O5; EINECS 201-788-0; Adonito; Fluorette; Kylit; xylo-Pentitol; Xylitol [INN:BAN:JAN:NF]; NSC-25283; DL-Arabinit; Xylitol C; HSDB 7967; Xylitab DC; Wood sugar alcohol; RB0; Xylitol,(S); EINECS 207-685-7; Ribitol (Adonitol); Adonitol (7CI); Xylisorb 300; Xylisorb 700; NSC 16868; Xylitab 100; Xylitab 300; BRN 1720524; D-ribitol (incorrect); L-ribitol (incorrect); Adonitol, >=99%; (2R,4S)-pentane-1,2,3,4,5-pentol; Xylitol, >=99%; bmse000062; bmse000129; bmse000886; Epitope ID:114702; Epitope ID:114703; EC 201-788-0; SCHEMBL4250; Xylitol, analytical standard; DSSTox_CID_22514; DSSTox_RID_80046; DSSTox_GSID_42514; SCHEMBL15318; MLS002695898; CHEMBL96783; Ribitol (6CI,8CI,9CI); INS NO.967; QSPL 191; SCHEMBL1924966; CHEMBL1865120; CHEMBL3137744; DTXSID7042514; INS-967; HY-N0538; Tox21_201056; s2612; s4546; ZINC18068098; AKOS015903403; AKOS015915193; ZINC100014205; ZINC100018612; CCG-214167; CCG-266218; CS-6043; DB01904; DB11195; DB14704; CAS-87-99-0; (2S,4R)pentane-1,2,3,4,5-pentaol; NCGC00165982-01; NCGC00165982-02; NCGC00258609-01; NCGC00390798-01; Adonitol, BioXtra, >=99.0% (HPLC); AS-55964; DS-11416; E967; K573; SMR001562099; HY-100582; Xylitol, Vetec(TM) reagent grade, >=99%; A0171; E-967; N1725; ST50411707; SW220290-1; Xylite 1000 microg/mL in Acetonitrile:Water; 2088-EP2272822A1; 2088-EP2275417A2; 2088-EP2284162A2; 2088-EP2284163A2; 2088-EP2292234A1; 2088-EP2292612A2; 2088-EP2301938A1; 2088-EP2305254A1; 2088-EP2311842A2; 2088-EP2314584A1; 2088-EP2371811A2; 2088-EP2377849A2; Adonitol, BioReagent, suitable for cell culture; C00379; C00474; K-9195; X-7000; WURCS=2.0/1,1,0/[h212h]/1/; WURCS=2.0/1,1,0/[h222h]/1/; 127873-EP2275398A1; 127873-EP2295402A2; 127873-EP2374783A1; 127873-EP2377841A1; Q212093; Q416534; (S)-1-BOC-2-METHYLSULFONYLETHYL-PIPERAZINE; Xylitol, European Pharmacopoeia (EP) Reference Standard; UNII-YFV05Y57M9 component HEBKCHPVOIAQTA-SCDXWVJYSA-N; UNII-YFV05Y57M9 component HEBKCHPVOIAQTA-ZXFHETKHSA-N; 5DCF4F57-E023-469A-B4F3-91E8349A6705; Xylitol, United States Pharmacopeia (USP) Reference Standard; 6684F574-C267-40CB-8828-12F2550E58D0; Xylitol, Pharmaceutical Secondary Standard; Certified Reference Material
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Species Origin Saccharomyces cerevisiae ...     Click to Show/Hide
Saccharomyces cerevisiae
Kingdom: Fungi
Phylum: Ascomycota
Class: Saccharomycetes
Order: Saccharomycetales
Family: Saccharomycetaceae
Genus: Saccharomyces
Species: Saccharomyces cerevisiae
Disease Food additive [ICD-11: N.A.] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C5H12O5
PubChem CID
6912
Canonical SMILES
C(C(C(C(CO)O)O)O)O
InChI
1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5?
InChIKey
HEBKCHPVOIAQTA-NGQZWQHPSA-N
CAS Number
CAS 87-99-0
ChEBI ID
CHEBI:15963
Herb ID
HBIN048522
SymMap ID
SMIT06577
TCMSP ID
MOL004712
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Chlorhexidine      Bacterial infection     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Experimental
                    Result(s)		 The XYL + CHX combination was efficient and superior to single treatments in controlling biofilm and suppressing S. mutans.
          Sucrose      Pain     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Obsborne-Mendel rats were inoculated once with a heavy suspension of S. mutans 50B4, serotype d, of human origin.
                    Experimental
                    Result(s)		 This study confirms the suggested therapeutic effect of xylitol even when mixed with sucrose, while nonspecific effects were eliminated.
References
Reference 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Reference 2 Antimicrobial effects of the combination of chlorhexidine and xylitol. Br Dent J. 2010 Dec 18;209(12):E19.
Reference 3 Anti-cariogenic and remineralizing properties of xylitol in combination with sucrose in rats inoculated with Streptococcus mutans. Caries Res. 1984;18(3):269-77.
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