Drug Combination Details

General Information of the Combination (ID: C45186)
Name Acorus calamus + Azoles + Amphotericin B
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Name Acorus calamus   NP Info     Drug Info 
Structure
Name    Drug Info 
Structure
Disease
Candidosis [ICD-11: 1F23]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model Candida species Microorganism model Candida species
                    Experimental
                    Result(s)		 The combined effects of asarones and drugs principally recorded substantial synergistic activity (fractional inhibitory concentration index (FICI) <0.5).
References
Reference 1 Asarones from Acorus calamus in combination with azoles and amphotericin B: a novel synergistic combination to compete against human pathogenic Candida species in vitro. Appl Biochem Biotechnol. 2015 Apr;175(8):3683-95.
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