Natural Product (NP) Details

General Information of the NP (ID: NP5166)
Name
Acorus calamus
Species Origin Acorus calamus ...     Click to Show/Hide
Acorus calamus
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Acorales
Family: Acoraceae
Genus: Acorus
Species: Acorus calamus
Disease Lung cancer [ICD-11: 2C25] Investigative [1]
Herb ID
HERB000164
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Azoles + Amphotericin B     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model Candida species Microorganism model Candida species
                    Experimental
                    Result(s)		 The combined effects of asarones and drugs principally recorded substantial synergistic activity (fractional inhibitory concentration index (FICI) <0.5).
References
Reference 1 Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice. Bull Exp Biol Med. 2017 Nov;164(1):102-105.
Reference 2 Asarones from Acorus calamus in combination with azoles and amphotericin B: a novel synergistic combination to compete against human pathogenic Candida species in vitro. Appl Biochem Biotechnol. 2015 Apr;175(8):3683-95.
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