Drug Combination Details
| General Information of the Combination (ID: C45271) | |||||
|---|---|---|---|---|---|
| Name | 1-deoxynojirimycin NP Info | + | Ibuprofen Drug Info | ||
| Structure |
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+ |
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| Disease |
Parkinson's disease
[ICD-11: 8A00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Animal models of Parkinson's disease (PD) were used in this study. | |||||
| Experimental
Result(s) |
MPTP induced death of dopaminergic neurons, microgliosis, increase of gliapses, motor impairment and neuroinflammation in mice, which were inhibited by combined 1-deoxynojirimycin and ibuprofen treatment. | |||||
