Natural Product (NP) Details

General Information of the NP (ID: NP9303)
Name
1-deoxynojirimycin
Synonyms
1-DEOXYNOJIRIMYCIN; 19130-96-2; DUVOGLUSTAT; Moranoline; deoxynojirimycin; (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Deoxy-1,5-imino-D-mannitol; Moranolin; 1,5-Dideoxy-1,5-imino-D-glucitol; UNII-FZ56898FLE; C6H13NO4; D-1-deoxynojirimycin; (+)-1-DEOXYNOJIRIMYCIN; S-GI; (2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol; 1-deoxynojirimycin (DNJ); 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-; CHEMBL307429; FZ56898FLE; DNJ; CHEBI:44369; 1-Deoxy-Nojirimycin; MFCD00063474; 5-Amino-1,5-dideoxy-D-glucopyranose; (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol; 1 Deoxynojirimycin; 1oim; Antibiotic S-GI; BAY-h-5595; DNM; 70956-02-4; Duvoglustat [USAN:INN]; BAY-h 5595; 1-Deoxynojirimicin; NOJ; PubChem21441; Duvoglustat (USAN/INN); EC 606-239-2; SCHEMBL2969; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-; BSPBio_000993; GTPL4642; BDBM18351; DTXSID70172647; 2j77; Bio1_000415; Bio1_000904; Bio1_001393; HMS1792A15; HMS1990A15; HMS3267J09; HMS3403A15; 1,5-dideoxy-1,5-imino-d-glucito; AMY37043; ZINC3794714; s3839; 1,5-didesoxy-1,5-imino-D-glucitol; 1, 5-dideoxy-1,5-imino-D-glucitol; AKOS006275143; 1-Deoxynojirimycin, analytical standard; AC-1386; CCG-266301; CS-5594; DB03206; SMP2_000333; NCGC00025085-02; NCGC00025085-03; BS-15755; HY-14860; S606; N1659; 30D962; A14383; C16843; D09605; SR-01000597392; Q-100789; SR-01000597392-1; W-201703; Q15274561; (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10
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Species Origin Commelina communis ...     Click to Show/Hide
Commelina communis
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Commelinales
Family: Commelinaceae
Genus: Commelina
Species: Commelina communis
Disease Inborn carbohydrate metabolism error [ICD-11: 5C51] Phase 3 [1]
Structure
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2D MOL

3D MOL

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Formula
C6H13NO4
PubChem CID
29435
Canonical SMILES
C1C(C(C(C(N1)CO)O)O)O
InChI
1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey
LXBIFEVIBLOUGU-JGWLITMVSA-N
CAS Number
CAS 19130-96-2
ChEBI ID
CHEBI:44369
Herb ID
HBIN002487
SymMap ID
SMIT15002
TTD Drug ID
D0S5LT
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Indomethacin      Rheumatoid arthritis     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Phosphorylation p105  Molecule Info 
Pathway MAP
                    In-vivo Model A GU mouse model was induced by indomethacin
                    Experimental
                    Result(s)		 DNJ showed protection for gastric functions of GU mice by reducing the levels of MOT and SP, and increasing the levels of SS and VIP.
          Ibuprofen      Pain     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Animal models of Parkinson's disease (PD) were used in this study.
                    Experimental
                    Result(s)		 MPTP induced death of dopaminergic neurons, microgliosis, increase of gliapses, motor impairment and neuroinflammation in mice, which were inhibited by combined 1-deoxynojirimycin and ibuprofen treatment.
Target and Pathway
Target(s) Intestinal maltase-glucoamylase (MGAM)  Molecule Info  [4]
Lysosomal alpha-glucosidase (GAA)  Molecule Info  [5]
KEGG Pathway Galactose metabolism Click to Show/Hide
2 Starch and sucrose metabolism
3 Metabolic pathways
4 Carbohydrate digestion and absorption
5 Lysosome
Pathwhiz Pathway Starch and Sucrose Metabolism Click to Show/Hide
2 Galactose Metabolism
Pathway Interaction Database Notch-mediated HES/HEY network Click to Show/Hide
WikiPathways Metabolism of carbohydrates Click to Show/Hide
References
Reference 1 The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase. Hum Mutat. 2009 Dec;30(12):1683-92.
Reference 2 1-Deoxynojirimycin (DNJ) Ameliorates Indomethacin-Induced Gastric Ulcer in Mice by Affecting NF-kappaB Signaling Pathway. Front Pharmacol. 2018 Apr 19;9:372.
Reference 3 Combined 1-Deoxynojirimycin and Ibuprofen Treatment Decreases Microglial Activation, Phagocytosis and Dopaminergic Degeneration in MPTP-Treated Mice. J Neuroimmune Pharmacol. 2021 Jun;16(2):390-402.
Reference 4 Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. J Med Chem. 1994 Oct 28;37(22):3701-6.
Reference 5 In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6.
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