Drug Combination Details
| General Information of the Combination (ID: C47047) | |||||
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| Name | Cinobufotalin + Paclitaxel | + | Cisplatin + 5-fluorouracil | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Cinobufotalin NP Info | Drug Info | |||
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| Name | Paclitaxel NP Info | Drug Info | |||
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| Disease |
Laryngeal cancer
[ICD-11: 2C23]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | UM-SCC-5 | CVCL_7762 | Laryngeal squamous cell carcinoma | Homo sapiens | ||
| FaDu | CVCL_1218 | Squamous cell carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
TPF regimen combining cinobufotalin suppressed proliferation and promoted apoptosis synergistically in hypopharyngeal squamous cell carcinoma and laryngeal squamous cell carcinoma cells. | |||||
