Drug Combination Details
| General Information of the Combination (ID: C48767) | |||||
|---|---|---|---|---|---|
| Name | Epigallocatechin gallate NP Info | + | Ibuprofen Drug Info | ||
| Structure |
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+ |
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| Disease |
Prostate cancer
[ICD-11: 2C82]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vitro Model | DU145 | CVCL_0105 | Prostate carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
EGCG+ibuprofen treatment has a synergistic effect on apoptosis, and xidative stress, directly or indirectly via ceramide synthesis mediated pro-apoptotic signaling. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic cell death by EGCG and ibuprofen in DU-145 prostate cancer cell line. Anticancer Res. Nov-Dec 2007;27(6B):3947-56. | |||
