Drug Combination Details
| General Information of the Combination (ID: C48805) | |||||
|---|---|---|---|---|---|
| Name | Trandolapril NP Info | + | Paricalcitol Drug Info | ||
| Structure |
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+ |
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| Disease |
Renal fibrosis
[ICD-11: MF54]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CCL5 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | COL1A1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | COL3A1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | FN1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | REN | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SNAI1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VIM | Molecule Info |
Pathway MAP
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| Experimental
Result(s) |
Combination therapy had additive efficacy in retarding renal scar formation during obstructive nephropathy. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy. Kidney Int. 2009 Dec;76(12):1248-57. | |||
