Drug Combination Details
| General Information of the Combination (ID: C48902) | |||||
|---|---|---|---|---|---|
| Name | Alpinumisoflavone NP Info | + | X-ray irradiation Drug Info | ||
| Structure |
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| Disease |
Esophageal cancer
[ICD-11: 2B70]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | GABPA | Molecule Info | ||
| Down-regulation | Expression | HMOX1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | NQO1 | Molecule Info |
Pathway MAP
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| In-vitro Model | Eca-109 | CVCL_6898 | Esophageal squamous cell carcinoma | Homo sapiens | ||
| KYSE-30 | CVCL_1351 | Esophageal squamous cell carcinoma | Homo sapiens | |||
| In-vivo Model | Approximately 1*106 Eca109 cells were suspended in 0.1 ml PBS and subcutaneously injected into the right leg of male BALB/c nude mice (5-week old). | |||||
| Experimental
Result(s) |
AIF functions as a potent radiosensitizer in human ESCC. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Alpinumisoflavone radiosensitizes esophageal squamous cell carcinoma through inducing apoptosis and cell cycle arrest. Biomed Pharmacother. 2017 Nov;95:199-206. | |||
