Drug Combination Details
| General Information of the Combination (ID: C51500) | |||||
|---|---|---|---|---|---|
| Name | Asiatic acid NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Renal failure
[ICD-11: GB60]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | SMAD7 | Molecule Info |
Pathway MAP
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| In-vivo Model | Twenty-four C57BL/6 male mice were used in this study | |||||
| Experimental
Result(s) |
Asiatic acid protects against cisplatin-induced AKI via anti-apoptosis and anti-inflammation. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation. Biomed Pharmacother. 2018 Nov;107:1354-1362. | |||
