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Drug Combination Details

General Information of the Combination (ID: C52446)
Name Streptozocin + 5-fluorouracil + Doxorubicin
    Click to Show/Hide the Each NP or Drug Information of This Combination
Name Streptozocin   NP Info     Drug Info 
Structure
Name    Drug Info 
Structure
Disease
Pancreatic endocrine tumor [ICD-11: 2E92]
Phase 2 [1]
Pancreatic cancer [ICD-11: 2C10]
Investigative [2]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Decreasing Adverse Drug Reaction by This Combination
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vivo Model Clinical trial
                    Experimental
                    Result(s)
The use of FAS before liver resection is associated with improved OS compared with surgery alone among patients with advanced synchronous pancreatic neuroendocrine liver metastases.
References
Reference 1 ClinicalTrials.gov (NCT00001165) Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas.
Reference 2 Preoperative Fluorouracil, Doxorubicin, and Streptozocin for the Treatment of Pancreatic Neuroendocrine Liver Metastases. Ann Surg Oncol. 2018 Jun;25(6):1709-1715.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China