Drug Combination Details
| General Information of the Combination (ID: C54033) | |||||
|---|---|---|---|---|---|
| Name | Abrin NP Info | + | Cyclophosphamide Drug Info | ||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Mice bearing intramuscularly growing Lewis lung carcinoma were used as animal model in this study. | |||||
| Experimental
Result(s) |
Small to moderate doses of abrin significantly potentiated the therapeutic effect of cyclophosphamide without increasing the toxicity. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Treatment of micrometastases from Lewis lung carcinoma with abrin and cyclophosphamide, given singly and in combination. Int J Cancer. 1979 Apr 15;23(4):530-5. | |||
