Natural Product (NP) Details

General Information of the NP (ID: NP6778)
Name
Abrin
Species Origin Abrus precatorius ...     Click to Show/Hide
Abrus precatorius
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Fabales
Family: Fabaceae
Genus: Abrus
Species: Abrus precatorius
Disease Renal cell carcinoma [ICD-11: 2C90] Investigative [1]
Herb ID
HBIN014235
SymMap ID
SMIT02316
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Cyclophosphamide      Solid tumour/cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Mice bearing intramuscularly growing Lewis lung carcinoma were used as animal model in this study.
                    Experimental
                    Result(s)		 Small to moderate doses of abrin significantly potentiated the therapeutic effect of cyclophosphamide without increasing the toxicity.
References
Reference 1 Antitumour effect of abrin on transplanted tumours in mice. Indian J Physiol Pharmacol. 2002 Jan;46(1):69-77.
Reference 2 Treatment of micrometastases from Lewis lung carcinoma with abrin and cyclophosphamide, given singly and in combination. Int J Cancer. 1979 Apr 15;23(4):530-5.
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