Natural Product (NP) Details

General Information of the NP (ID: NP6778)
Name
Abrin
Species Origin Abrus precatorius ...     Click to Show/Hide
Abrus precatorius
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Fabales
Family: Fabaceae
Genus: Abrus
Species: Abrus precatorius
Disease Renal cell carcinoma [ICD-11: 2C90] Investigative [1]
ADMET Property
Absporption
Caco-2 Permeability
 -5.923
 
MDCK Permeability
 -5.001
 
PAMPA
 +++
 
HIA
 - - -
 
Distribution
VDss
 0.114
 
PPB
 46%
 
BBB
 - - -
 
Metabolism
CYP1A2 inhibitor
 - - -
CYP1A2 substrate
 - - -
CYP2C19 inhibitor
 - - -
CYP2C19 substrate
 - - -
CYP2C9 inhibitor
 - - -
CYP2C9 substrate
 - - -
CYP2D6 inhibitor
 - - -
CYP2D6 substrate
 ++
CYP3A4 inhibitor
 - - -
CYP3A4 substrate
 - - -
CYP2B6 inhibitor
 - - -
CYP2B6 substrate
 - - -
CYP2C8 inhibitor
 - - -
HLM Stability
 - - -
 
Excretion
CLplasma
 3.402
 
T1/2
 1.334
Toxicity
DILI
 +
 
Rat Oral Acute Toxicity
 - -
 
FDAMDD
 ++
 
Respiratory
 - -
 
Human Hepatotoxicity
 +++
 
Ototoxicity
 ++
 
Drug-induced Nephrotoxicity
 +++
 
Drug-induced Neurotoxicity
 ++
 
Hematotoxicity
 - -
 
Genotoxicity
 ++
 
Tips: 1. For the classification endpoints, the prediction probability values are transformed into six symbols: 0-0.1 (- - -), 0.1-0.3 (- -), 0.3-0.5 (-), 0.5-0.7 (+), 0.7-0.9 (++), and 0.9-1.0 (+++). 2. Additionally, the corresponding relationships of the three labels are as follows: excellent; medium; poor.
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Herb ID
HBIN014235
SymMap ID
SMIT02316
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Cyclophosphamide      Solid tumour/cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Mice bearing intramuscularly growing Lewis lung carcinoma were used as animal model in this study.
                    Experimental
                    Result(s)		 Small to moderate doses of abrin significantly potentiated the therapeutic effect of cyclophosphamide without increasing the toxicity.
References
Reference 1 Antitumour effect of abrin on transplanted tumours in mice. Indian J Physiol Pharmacol. 2002 Jan;46(1):69-77.
Reference 2 Treatment of micrometastases from Lewis lung carcinoma with abrin and cyclophosphamide, given singly and in combination. Int J Cancer. 1979 Apr 15;23(4):530-5.
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