Drug Combination Details
| General Information of the Combination (ID: C55332) | |||||
|---|---|---|---|---|---|
| Name | Omega-3 PUFAs NP Info | + | Proanthocyanidins Drug Info | ||
| Structure |
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+ |
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| Disease |
Hypertriglyceridaemia
[ICD-11: 5C80]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Down-regulation | Bifidobacterium secretion | ||||
| Up-regulation | Lactobacillus secretion | |||||
| In-vivo Model | A total of twenty-eight female Wistar-Kyoto rats aged 8-10 weeks were used in this study. | |||||
| Experimental
Result(s) |
Combined supplementation of Omega-3 PUFAs and proanthocyanidins from grape seed counteracts the effects of the Omega-3 PUFAs on health-promoting lactobacillus and bifidobacterium, and on acetic acid, while maintaining their beneficial effects on cholesterolemia. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effects of the combination of Omega-3 PUFAs and proanthocyanidins on the gut microbiota of healthy rats. Food Res Int. 2017 Jul;97:364-371. | |||
