Natural Product (NP) Details
| General Information of the NP (ID: NP7746) | |||||
|---|---|---|---|---|---|
| Name |
Omega-3 PUFAs
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| Species Origin | phytoplankton environmental sample ... | Click to Show/Hide | |||
| phytoplankton environmental sample | |||||
| Disease | Periodontal disease [ICD-11: DA0C] | Phase 4 | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Naproxen | Osteoarthritis | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Down-regulation | Expression | VCAM1 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Decrease | Serum TG | ||||
| In-vivo Model | Clinical trial | |||||
| Experimental
Result(s) |
Combining NX with omega-3 PUFAs increases their effectiveness in reducing serum TG and favorably altering AT gene expression and plasma bile acid profile. | |||||
| Proanthocyanidins | Atherosclerosis | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
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| Biological
Regulation |
Down-regulation | Bifidobacterium secretion | ||||
| Up-regulation | Lactobacillus secretion | |||||
| In-vivo Model | A total of twenty-eight female Wistar-Kyoto rats aged 8-10 weeks were used in this study. | |||||
| Experimental
Result(s) |
Combined supplementation of Omega-3 PUFAs and proanthocyanidins from grape seed counteracts the effects of the Omega-3 PUFAs on health-promoting lactobacillus and bifidobacterium, and on acetic acid, while maintaining their beneficial effects on cholesterolemia. | |||||
