Drug Combination Details
| General Information of the Combination (ID: C55540) | |||||
|---|---|---|---|---|---|
| Name | Sulforaphane NP Info | + | Decitabine Drug Info | ||
| Structure |
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+ |
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| Disease |
Melanoma
[ICD-11: 2C30]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | B16-F10 | CVCL_0159 | Mouse melanoma | Mus musculus | ||
| Experimental
Result(s) |
combinational treatments with SFN and DAC results in melanoma cell growth inhibition and specific changes in gene expression profiles. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effect of Sulforaphane and 5-Aza-2'-Deoxycytidine on Melanoma Cell Growth. Medicines (Basel). 2019 Jun 27;6(3):71. | |||
