Drug Combination Details
| General Information of the Combination (ID: C57631) | |||||
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| Name | Gamma tocotrienol + Vitamin E | + | Celecoxib | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Gamma tocotrienol NP Info | Drug Info | |||
| Structure |
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| Name | Vitamin E NP Info | ||||
| Structure |
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| Disease |
Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | +SA mammary epithelial cells' | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Combination therapy with these agents may provide enhanced therapeutic response in breast cancer patients, while avoiding the toxicity associated with high-dose COX-2 inhibitor monotherapy. | |||||
