Drug Combination Details
| General Information of the Combination (ID: C58595) | |||||
|---|---|---|---|---|---|
| Name | Pseudoephedrine NP Info | + | Domperidone Drug Info | ||
| Structure |
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+ |
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| Disease |
Obstructive sleep apnea
[ICD-11: 7A41]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Experimental
Result(s) |
The combination of domperidone and pseudoephedrine improved self reported snoring and sleepiness, and may have improved apneic episodes and sleep-related nocturnal oxygen desaturation in patients with obstructive sleep apnea provided the proportion of time spent asleep did not diminish. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Pharmacological treatment of obstructive sleep apnea with a combination of pseudoephedrine and domperidone. J Clin Sleep Med. 2010 Apr 15;6(2):117-23. | |||
