Drug Combination Details
| General Information of the Combination (ID: C60387) | |||||
|---|---|---|---|---|---|
| Name | Artesunate NP Info | + | Tetramethylpyrazine Drug Info | ||
| Structure |
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+ |
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| Disease |
Malaria
[ICD-11: 1F40]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BDNF | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | GFAP | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | ICAM1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | NGF | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | NTF3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VCAM1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vivo Model | For a xenograft model, 1 * 106 parasitized red blood cells (pRBCs) were injectedinto C57BL/6 mice via intraperitoneal (i.p.). | |||||
| Experimental
Result(s) |
The neuroprotective effects of artesunate + tetramethylpyrazine were mainly related to proteins involved in axon development and transportation between blood and brain. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic Effect of Combined Artesunate and Tetramethylpyrazine in Experimental Cerebral Malaria. ACS Infect Dis. 2020 Sep 11;6(9):2400-2409. | |||
