Drug Combination Details
| General Information of the Combination (ID: C62867) | |||||
|---|---|---|---|---|---|
| Name | Magnesium NP Info | + | Simvastatin Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Hypertriglyceridaemia
[ICD-11: 5C80]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | C57BL/6 male mice were fed with a HFD or a normal-fat diet (NFD). | |||||
| Experimental
Result(s) |
The combination of Mg2+ and SIM shows a synergistic effect on attenuating the HFD-induced bone loss. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss. Bioact Mater. 2021 Feb 3;6(8):2511-2522. | |||
