Drug Combination Details

General Information of the Combination (ID: C68723)
Name Vincristine   NP Info  + Topotecan   Drug Info 
Structure +
Disease
Brain cancer [ICD-11: 2A00]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model Rh18 CVCL_1659 Alveolar rhabdomyosarcoma Homo sapiens
D283 Med CVCL_1155 Medulloblastoma Homo sapiens
Daoy CVCL_1167 Medulloblastoma Homo sapiens
SJ-GBM2 CVCL_M141 Glioblastoma Homo sapiens
NB-EB Neuroblastoma Homo sapiens
RMSs Embryonal rhabdomyosarcoma Homo sapiens
                    Experimental
                    Result(s)		 The therapeutic effect of combining topotecan with vincristine was greater than additive in most tumor models of childhood solid tumors tested.
References
Reference 1 Synergy of topotecan in combination with vincristine for treatment of pediatric solid tumor xenografts. Clin Cancer Res. 1999 Nov;5(11):3617-31.
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