Drug Combination Details

General Information of the Combination (ID: C71805)
Name Geraniol   NP Info  + 5-fluorouracil   Drug Info 
Structure +
Disease
Colorectal cancer [ICD-11: 2B91]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression TYMS  Molecule Info 
Pathway MAP
                    In-vitro Model Caco-2 CVCL_0025 Colon adenocarcinoma Homo sapiens
SW620 CVCL_0547 Colon adenocarcinoma Homo sapiens
                    In-vivo Model Colorectal tumor TC118 obtained from patients was grafted by subcutaneous implantation of 15 mm3 tumor fragments into the scapular area of nude mice.
                    Experimental
                    Result(s)		 Geraniol modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts.
References
Reference 1 Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett. 2004 Nov 8;215(1):53-9.
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