Natural Product (NP) Details
| General Information of the NP (ID: NP2294) | |||||
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| Name |
Geraniol
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| Synonyms |
GERANIOL; 106-24-1; Lemonol; Geranyl alcohol; trans-Geraniol; (E)-Geraniol; (2E)-3,7-dimethylocta-2,6-dien-1-ol; (E)-Nerol; trans-3,7-Dimethyl-2,6-octadien-1-ol; (E)-3,7-Dimethylocta-2,6-dien-1-ol; Geraniol Extra; Geraniol alcohol; 3,7-Dimethyl-2,6-octadien-1-ol; (E)-3,7-Dimethyl-2,6-octadien-1-ol; beta-Geraniol; 3,7-Dimethyl-trans-2,6-octadien-1-ol; 2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-; Guaniol; t-geraniol; 2E-geraniol; Geraniol (natural); 2-trans-3,7-Dimethyl-2,6-octadien-1-ol; 2,6-Octadien-1-ol, 3,7-dimethyl-; CHEBI:17447
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| Species Origin | Rosa rugosa ... | Click to Show/Hide | |||
| Rosa rugosa | |||||
| Agave amica | |||||
| Trigonotis peduncularis | |||||
| Abutilon indicum | |||||
| Podaxis carcinomalis | |||||
| Disease | Osteoarthritis [ICD-11: FA00-FA05] | Investigative | [1] | ||
| Structure |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
| Formula |
C10H18O
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| PubChem CID | |||||
| Canonical SMILES |
CC(=CCCC(=CCO)C)C
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| InChI |
1S/C10H18O/c1-9(2)5-4-6-10(3)7-8-11/h5,7,11H,4,6,8H2,1-3H3/b10-7+
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| InChIKey |
GLZPCOQZEFWAFX-JXMROGBWSA-N
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| CAS Number |
CAS 106-24-1
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| 5-fluorouracil | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Down-regulation | Expression | TYMS | Molecule Info |
Pathway MAP
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| In-vitro Model | Caco-2 | CVCL_0025 | Colon adenocarcinoma | Homo sapiens | ||
| SW620 | CVCL_0547 | Colon adenocarcinoma | Homo sapiens | |||
| In-vivo Model | Colorectal tumor TC118 obtained from patients was grafted by subcutaneous implantation of 15 mm3 tumor fragments into the scapular area of nude mice. | |||||
| Experimental
Result(s) |
Geraniol modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. | |||||
| Simvastatin | Hyper-lipoproteinaemia | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
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| Biological
Regulation |
Inhibition | Cholesterol biosynthesis | ||||
| In-vitro Model | Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line. | |||||
| Gemcitabine | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [4] | |||||
| Detail(s) |
Combination Info
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| In-vitro Model | BxPC-3 | CVCL_0186 | Pancreatic ductal adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Geraniol significantly increased the antiproliferative and apoptosis-inducing effects of gemcitabine on BXPC-3 cells. | |||||
| Target and Pathway | ||||
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| Target(s) | Transient receptor potential channel 8 (TRPM8) | Molecule Info | [5] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | Click to Show/Hide | ||
| Reactome | TRP channels | Click to Show/Hide | ||
