Drug Combination Details
| General Information of the Combination (ID: C72760) | |||||
|---|---|---|---|---|---|
| Name | Paclitaxel NP Info | + | Dichloroacetate Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Lip/oral cavity/pharynx neoplasm
[ICD-11: 2B6E]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CYB5R2 | Molecule Info |
Pathway MAP
|
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| In-vitro Model | OECM-1 | CVCL_6782 | Gingival squamous cell carcinoma | Homo sapiens | ||
| SAS | CVCL_1675 | Tongue squamous cell carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
The combination of Taxol with DCA showed synergistic inhibitory effects on Taxol resistant cells under hypoxic conditions. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combination of Taxol? and dichloroacetate results in synergistically inhibitory effects on Taxol-resistant oral cancer cells under hypoxia. Mol Med Rep. 2015 Apr;11(4):2935-40. | |||
