Drug Combination Details

General Information of the Combination (ID: C73681)
Name Celastrol   NP Info  + Cisplatin   Drug Info 
Structure +
Disease
Metastatic lymph node neoplasm [ICD-11: 2D60]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Reversing Drug Resistance by This Combination
                 Reversing Drug Resistance     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression SPC25  Molecule Info 
Pathway MAP
                    In-vitro Model SAS CVCL_1675 Tongue squamous cell carcinoma Homo sapiens
CGHNC8 Oral squamous cell carcinoma cells Homo sapiens
                    Experimental
                    Result(s)		 Celastrol effectively inhibit SPC25 expression and reverse CR phenotype.
References
Reference 1 A Combined Systemic Strategy for Overcoming Cisplatin Resistance in Head and Neck Cancer: From Target Identification to Drug Discovery. Cancers (Basel). 2020 Nov 23;12(11):3482.
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